Doppleganger
06-30-2007, 10:50 PM
According to the study published in Science magazine, the scientists engineered an enzyme which attacks the DNA of the HIV virus and cuts it out of the infected cell.
The enzyme is still far from being ready to use as a treatment, the authors warned, but it offers a glimmer of hope for the more than 40 million people infected worldwide.
"A customised enzyme that effectively excises integrated HIV-1 from infected cells in vitro might one day help to eradicate (the) virus from AIDS patients," Alan Engelman, of Harvard University's Dana-Farber Cancer Institute, wrote in an article accompanying the study.
Current treatments focus on suppressing the HIV virus in order to delay the onset of AIDS and dramatically extend the life of infected patients.
What makes HIV so deadly, however, is its ability to insert itself into the body's cells and force those cells to produce new infection.
"Consequently the virus becomes inextricably linked to the host, making it virtually impossible to 'cure' AIDS patients of their HIV-1 infection," Professor Engelman explained.
That could change if the enzyme developed by a group of German scientists can be made safe to use on people.
That enzyme was able to eliminate the HIV virus from infected human cells in about three months in the laboratory.
The researchers engineered an enzyme called 'Tre' which removes the virus from the genome of infected cells by recognising and then recombining the structure of the virus's DNA.
This ability to recognise HIV's DNA might one day help overcome one of the biggest obstacles to finding a cure: the ability of the HIV virus to avoid detection by reverting to a resting state within infected cells which then cease to produce the virus for months or even years.
"Numerous attempts have been made to activate these cells, with the hope that such strategies would sensitise the accompanying viruses to antiviral drugs, leading to virus eradication," Professor Engelman wrote. "Advances with such approaches in patients have been slow to materialise."
New experiments must be designed to see if the Tre enzyme can be used to recognise these dormant infected cells, he wrote.
"Although favourable results would represent perhaps only a baby step toward eventual use in patients, the discovery of the Tre recombinase proves that enzymatic removal of integrated HIV-1 from human chromosomes is a current-day reality," he said.
The researchers who developed the enzyme were optimistic about their ability to design additional enzymes which would target other parts of the virus's DNA.
However they warned that there were significant barriers to overcome before the enzyme could be used to help cure patients.
Source (http://abc.net.au/news/stories/2007/06/29/1966051.htm?section=world).
The enzyme is still far from being ready to use as a treatment, the authors warned, but it offers a glimmer of hope for the more than 40 million people infected worldwide.
"A customised enzyme that effectively excises integrated HIV-1 from infected cells in vitro might one day help to eradicate (the) virus from AIDS patients," Alan Engelman, of Harvard University's Dana-Farber Cancer Institute, wrote in an article accompanying the study.
Current treatments focus on suppressing the HIV virus in order to delay the onset of AIDS and dramatically extend the life of infected patients.
What makes HIV so deadly, however, is its ability to insert itself into the body's cells and force those cells to produce new infection.
"Consequently the virus becomes inextricably linked to the host, making it virtually impossible to 'cure' AIDS patients of their HIV-1 infection," Professor Engelman explained.
That could change if the enzyme developed by a group of German scientists can be made safe to use on people.
That enzyme was able to eliminate the HIV virus from infected human cells in about three months in the laboratory.
The researchers engineered an enzyme called 'Tre' which removes the virus from the genome of infected cells by recognising and then recombining the structure of the virus's DNA.
This ability to recognise HIV's DNA might one day help overcome one of the biggest obstacles to finding a cure: the ability of the HIV virus to avoid detection by reverting to a resting state within infected cells which then cease to produce the virus for months or even years.
"Numerous attempts have been made to activate these cells, with the hope that such strategies would sensitise the accompanying viruses to antiviral drugs, leading to virus eradication," Professor Engelman wrote. "Advances with such approaches in patients have been slow to materialise."
New experiments must be designed to see if the Tre enzyme can be used to recognise these dormant infected cells, he wrote.
"Although favourable results would represent perhaps only a baby step toward eventual use in patients, the discovery of the Tre recombinase proves that enzymatic removal of integrated HIV-1 from human chromosomes is a current-day reality," he said.
The researchers who developed the enzyme were optimistic about their ability to design additional enzymes which would target other parts of the virus's DNA.
However they warned that there were significant barriers to overcome before the enzyme could be used to help cure patients.
Source (http://abc.net.au/news/stories/2007/06/29/1966051.htm?section=world).